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Multiple Choice Questions « Return to contents list Chapter 13, Question 1.13.1 Congenital absence of which surfactant protein (SP) is most likely to be lethal in the neonatal period? A SP-A.[Feedback :- Surfactant protein A is only marginally involved in lowering the surface, but does play an important role in the innate lung defence barrier against pathogenic organisms. Congenital absence of SP-B is lethal in the neonatal period.] B SP-B.This is the Correct Answer [Feedback :- Congenital absence of surfactant protein B is lethal in the neonatal period.] C SP-C.[Feedback :- Surfactant protein C deficiency is not associated with respiratory failure at birth, but may lead to interstitial lung disease in later childhood. Congenital absence of SP-B is lethal in the neonatal period.] D SP-D.[Feedback :- Surfactant protein B is only marginally involved in lowering the surface but does play an important role in the innate lung defence barrier against pathogenic organisms. Congenital absence of SP-B is lethal in the neonatal period.] E SP-E.[Feedback :- There are four major surfactant proteins (A, B, C and D). Congenital absence of SP-B is lethal in the neonatal period.]